Annotated Bibliography
Xiaobin B. Zhao and Robert J. Lee (2004). Tumor-selective targeted delivery of genes and antisense oligodeoxyribonucleotides via the folate receptor. Advanced Drug Delivery Reviews, Volume 56, Issue 8, 29 April 2004, Pages 1193-1204. The article affirms the importance of gene therapy for the treatment of cancer ad discusses that the main obstacle for treating cancer by gene therapy is the lavk of safe and effective transfer vectors. The novel approach of viral and non viral vectors is described as the emerging method used for gene delivery via cellular receptors.
Detailed explanation is provided about the folate receptor (FR) and the advantages of FR targeted vectors are discussed. MP Turunen, MO Hiltunen, S Yla-Herttuala (1999). Gene therapy for angiogenesis, restenosis and related diseases. Experimental Gerontology, Volume 34, Number 4, August 1999 , pp. 567-574(8). The article discusses the use of gene therapy for the treatment of atherosclerosis and disease related to it. The ways in which gene transfer can be performed has been discusses in addition to the other options which can be used for the transfer.
The article promises good scope of the treatment but concludes that additional research is required in order to comprehend well the mechanisms which relate to atherosclerosis. The article also asserts that research and developments are necessary for gene transfer vectors and gene delivery techniques in order to improve the efficiency of gene therapy. Neider H, Harbottle RP, Yokosaki Y, Jost P, Coutelle C. (1999), Targeted gene delivery into alpha9beta1-integrin-displaying cells by a synthetic peptide.
FEBS. 24;458(3):329-32 The authors discuss the benefits of two synthetic peptides which would be helpful on the successful completion of specific gene delivery. Properties of the integrin alpha9beta1 gene are discussed and its applicability in the treatment of prenatal and cancer gene therapy have been described. Tan, Mei Lin, Choong, Peter F. M. ,Dass, Crispin R. , (2009). Cancer, chitosan nanoparticles and catalytic nucleic acids. Journal of Pharmacy and Pharmacology, Volume 61, Number 1, pp. 3-12(10). Pharmaceutical Press
In this article, the authors review the status of the current and future of gene therapy which involves the DNA enzyme and the encapsulation of siRNA into nanoparticles. The authors find that cancer is a disease in which the body cells undergo mutations and transformations at the genetic level and duplicate rapidly. The treatment involves the use of surgery and chemotherapy and the new forms of immunotherapy and gene therapy have shown promise but need methods to limit the exposure of the body to cancerous lesions.
A recent system of drug delivery involves the use of chitosan nanoparticle technology in which therapeutics are encapsulated into Nan particles and are targeted to tumors. Havert MB. (2008). A regulatory perspective on the development of gene therapy for Parkinson’s disease. Exp Neurol. 209(1):48-50. Epub 2007 Aug 24. The article discusses the potential of gene therapy viruses to be used as vectors for delivering genetic matter and their benefits for Parkinson’s disease.
The article discusses the emerging branch of gene therapy and provides a summary of the regulatory process of investigational new drug (IND), while emphasizing some of the particular restraints for the disease. The article also pioneers the efforts of the FDA for reducing the gap between the discovery and introduction of gene therapies in clinical settings. C. Altaner. (2008). Prodrug cancer gene therapy. Cancer Letters, Volume 270, Issue 2, Pages 191-201
The article reviews the development, application and the potential of the many types of Gene Directed Prodrug therapy (GDEP) which concentrates on the cytotoxic effect in the site of tumor. In particular, the article focuses on the limitations of current gene therapy and assesses the current status of the enhancement of GDEPT and targeting of tumor specific vectors. GDEPT versions of stem cell based gene therapy are discussed as the potential treatment for treating advanced tumors and metastases.
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